Induction of prostaglandin endoperoxide synthase-2 in human monocytes associated with cyclo-oxygenase-dependent F2-isoprostane formation

Advances on prostaglandin - endoperoxide synthase 2 gene

Prostaglandin-endoperoxide synthase 2 is the rate-limiting enzyme in the biosynthesis of prostaglandins (PGs). In this paper, we briefly introduced the structure, expression, regulation mechanism of prostaglandinendoperoxide synthase 2 gene and the relationship between this gene and reproductive performance.

Induction of cyclo-oxygenase and nitric oxide synthase in inflammation.

PTGS 2 ( prostaglandin - endoperoxide synthase 2 ( prostaglandin G / H synthase and cyclooxygenase ) )

COX2 is an enzyme that belongs to the prostaglandin G/H synthase family. It consists of 604 amino acids and has a molecular weight of 68996 Da. COX2 possesses two catalytic activities and respective active sites: a cyclooxygenase (COX) that converts arachidonic acid to a prostaglandin endoperoxide, prostaglandin G2 (PGG2), and; a peroxidase (POX) that reduces PGG2 to PGH2. COX2 functions as hom...

Hydroxyl-radical formation during prostaglandin formation catalysed by prostaglandin cyclo-oxygenase [proceedings].

The results indicate that haptoglobin may account for at least part of the inhibitor activity of plasma or serum. This seems to be consistent with the finding that administration of glucocorticoids in rats induced parallel changes in plasma inhibitor activity and haptoglobin concentration. However, no clear relationship between the haptoglobin concentration and the inhibitory actions of several...

Prostaglandin endoperoxide H synthase expression in human thyroid epithelial cells.

KAT-50, an established human thyrocyte cell line, expresses constitutively high levels of prostaglandin endoperoxide H synthase-2 (PGHS-2), the inflammatory cyclooxygenase. Here, we examine primary human thyrocytes. We find that they, too, express PGHS-2 mRNA and protein under control culture conditions. A substantial fraction of the basal prostaglandin E(2) (PGE(2)) produced by these cells can...